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Watermark Medical (ARES™)
Sleep Apnea Diagnosis Research:

Sleep Apnea and Pediatrics:
The growing epidemic of childhood obesity and asthma has led to a significant increase in the number of children diagnosed with sleep apnea. Many parents would prefer the option of an in-home diagnostic study that could eliminate the need to spend the night in the sleep lab with their children. To address this need, ABM is working with Dr. Carol Rosen at Case Western Reserve University, one of the nation’s leading pediatric sleep specialists to validate the use of ARES in the pediatric population. The study, funded by NIH, evaluates the ARES in-home and in the laboratory with a group of patients between the ages of 12 and 18.

Sleep Apnea and Pregnancy:
Recent studies have shown that pregnancy-related weight gain increases risk for developing sleep apnea, particularly during the last trimester. The presence of sleep apnea during pregnancy increases risk for developing diabetes and high blood pressure -- including eclampsia and pre-eclampsia which can potentially threaten the life of the mother and result in low birth weight for babies. Most obstetricians are as yet unaware of sleep apnea and its consequences. The ARES will be used by Dr. Ghada Bourjeily, MD at Brown University to assess the onset and prevalence of undiagnosed OSA in a large group of women during pregnancy.

Forehead Venous Pressure as a Measure of Respiratory Effort:
Chest and abdomen effort belts are commonly used to monitor respiratory effort during sleep studies. ABM has developed a patent-pending alternative which measures respiratory effort using changes in forehead venous pressure (how it works). Christopher King, M.D. and his research team at Walter Reed Army Hospital Sleep Disorders Center is collaborating with Advanced Brain Monitoring to validate the ARES proprietary measure of respiratory effort using forehead venous pressure as compared to signals obtained with an esophageal balloon transducer. With further validation and development, surface measurement of venous pressure on the head or neck could substitute for central venous pressure recording.

Learn more about Forehead Venous Pressure and Measuring Respiratory Effort

Treatment of OSA with Mandibular Repositioning Device (MRD):
Continuous Positive Airway Pressure (CPAP) is the most prescribed treatment for OSA. In a pilot study, ABM and its dental collaborators reported a 96% efficacy rate when treating OSA with MRDs. In a Phase II NIH funded study, the research team will assess differences in outcomes comparing the TAP and Herbst appliances, improve upon the ARES algorithm for predicting successful treatment outcomes with MRDs, and validate a system designed to ensure dentists inexperienced in MRD therapy obtain similar treatment outcomes as expert dentists. Additionally, the study will compare changes in cognitive impairment of patients pre- and post-treatment with MRDs vs. CPAP (link to MAD abstract).

Sleep Apnea and the Hispanic/Latino Community:
The NIH Hispanic Health Study is the largest long-term comprehensive study of health and disease in the Hispanic/ Latino populations. A group of 16,000 participants of Hispanic/Latino origin will be studied as part of the 6 ½ year epidemiological study designed to identify the prevalence and risk factors for a wide variety of diseases, disorders and conditions, one of which will be obstructive sleep apnea. The ARES was selected to acquire sleep study data on all participants. ARES studies are being conducted by Dr. Susan Redline, the principal investigator at Case Western Reserve University who will oversee the analysis of all of the sleep study data.

Increased Sleep and Obesity:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH,) under the guidance of Dr. Giovanni Cizza, M.D., Ph.D., is conducting research to assess the impact of increased sleep time on weight loss. The research team is using the ARES to identify subjects with significant sleep apnea who should be excluded from their study. The ARES will also be used to assess changes in sleep disordered breathing of participants one year after enrollment in the study protocol.

WM ARES VALIDATION

WM ARES AND TREATMENT

WM DENTAL DOCUMENTATION

OSA AND CO-MORBIDITIES